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Binding to and phosphorylation of Sab by p-JNK leads to inactivation of p-Src on the inner mitochondrial membrane, which then inhibits electron transport and increases reactive oxygen species release [54,60], thus amplifying oxidant stress and peroxynitrite formation [42]

(2) Patients with major heart, liver, kidney, and other organ disorders, including co-infection with hepatitis C virus (HCV), hepatitis D virus (HDV), or other chronic liver diseases such as alcoholic liver disease, non-alcoholic fatty liver disease (NAFLD), and autoimmune hepatitis