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Semaglutide does not directly cause hemorrhoids, but it can lead to constipation, diarrhea, and dehydration, which may increase the risk
A 2024 pharmacovigilance analysis of a global drug safety database found that GLP-1 receptor agonists, including semaglutide, had reporting-odds ratios suggesting associations with depression, anxiety, and, in rare cases, suicidal ideation
22 Lower renal TAS has also been previously reported in 22-week-old SHR
Studies used reverse-phase high-performance liquid chromatography (RP-HPLC) and liquid chromatography high-resolution mass spectrometry (LC-HRMS) to identify and quantify semaglutide degradation products under various stress conditions
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