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Most are administered via small subcutaneous injection a few times per week, though some are available as nasal sprays (Semax/Selank), oral capsules (Dihexa), or topical formulations (GHK-Cu)

Therefore, although DPP-4 inhibition reduces both fasting and postprandial glucose and HbA 1c levels, the effects are weaker than for GLP-1 receptor agonists, and they do not exhibit a body weight reduction effect, although they are body weight neutral

doi: 10.1016/j.molmet.2018.09.009 45 GarveyWTFriasJPJastreboffAMle RouxCWSattarNAizenbergDet al