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In an adjunctive epilepsy trial in pediatric patients (2 to 16 years), skin disorder (3%), alopecia (2%), dermatitis (2%), hypertrichosis (2%), erythematous rash (2%), eczema (1%), seborrhea (1%), and skin discoloration (1%) occurred more frequently in topiramate-treated patients compared to patients given placebo

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Currently available data on body composition do not indicate an association of greater lean body mass loss over fat mass loss with semaglutide treatment, Novo Nordisk says