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Interestingly, GLUT2 is linked to K ATP channels (145) while SGLT1 is linked to voltage-gated sodium and calcium channels in GLP-1 secretion (218)

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in particular, one study reported the mechanism by which nucleus-tractus-solitarius-derived GLP-1 modulates neuronal activity and food intake behavior (through the following steps: GLP-1R signaling stimulates the PKA signaling pathway, which promotes phosphorylation of GluA1 S845, increasing GluA1 membrane trafficking and postsynaptic excitatory synaptic transmission), whereas alterations in the paraventricular nucleus of the hypothalamus GLP-1 signaling induced obesity [37]

Unraveling the role of epicardial adipose tissue in coronary artery disease: partners in crime