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Moreover, daily oscillations in RBF (19) generate substantial fluctuations in kidney tissue oxygenation (20) and metabolic substrate availability, thereby suggesting rhythmic changes in renal metabolic pathways

The resulting high levels of intrahepatic fat deposition, coupled with the persistent IR, accelerate the chronic inflammatory and fibrotic processes characteristic of advanced liver disease (Salmon et al., 2012)

This blend of support and personal responsibility creates a sustainable path for recovery