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Barton, the discussant, praised the trials rigorous methodology and proposed that there may have been several reasons for the lack of ALC benefit in preventing neuropathy, despite compelling earlier data

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2018: A double-blind, placebo-controlled study among women receiving taxane-based chemotherapy to treat breast cancer found that 3 grams of acetyl-L-carnitine taken daily for 5.5 months significantly WORSENED symptoms of chemotherapy-induced peripheral neuropathy compared to placebo, and this difference persisted after 2 years [7][28]

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