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Notably, the metabolic benefits of dual GLP-1R/GcgR agonists have also been documented in obese non-human primates, where chronic administration of a lower dose of a GLP-1R/GcgR co-agonist vs a GLP-1R mono-agonist reduced body weight and improved glucose tolerance to a greater degree [77]

Simone Braca, a neurologist and clinical researcher at the Headache Center at the University of Naples, Italy

Despite extensive research illustrating their potential as drug delivery systems, clinical translation continues to pose challenges due to low extraction purity and potential safety concerns [158]

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