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Evidence shows that certain 5-HT2A agonists with psychedelic properties, such as (R)-DOI (in primary rat aortic smooth muscle cells stimulated with TNF-), can inhibit NF-B nuclear translocation and suppress TNF--induced inflammatory gene expression in vitro, including ICAM-1, VCAM-1, and IL-6
Statistical analysis was performed via GraphPad Prism 9 software
Beyond the telomerase story, the literature describes effects on melatonin secretion, pineal function, antioxidant gene expression, immune function, and circadian regulation
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