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However, according to William Blair analysts, retatrutides tolerability profile could confine the drug to use in patients at the higher end of the BMI spectrum, while tirzepatide will continue to serve as the go-to medication, due to its balanced efficacy and tolerability profile. At the highest dose of retatrutide, 11.3% of participants discontinued treatment due to adverse effects

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The KFF poll also found that nearly one in five adults (18%) say at some point they have taken a GLP-1 drug, a class of medications used for weight loss and to treat diabetes, heart disease and other chronic conditions