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Methods Leveraging the target trial emulation framework, we conducted a retrospective study using observational data to emulate a new user, active comparator trial examining the effects of initiating GLP-1RA (exposure group) versus SGLT2 inhibitors (control group), with random treatment assignment emulated by propensity score matching with 1:1 ratio

Figure 3: Head-to-head efficacy comparison restricted to Standard-design, Non-T2D trials

Dosage and Administration 1,2 : Ertugliflozin is supplied as 5 mg- and 15-mg tablets

If you plateau on semaglutide, switching to tirzepatide or optimizing lifestyle factors typically produces better results than addition of orlistat