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doi: 10.1523/JNEUROSCI.0115-14.2014 [DOI] [PMC free article] [PubMed] [Google Scholar] 157.Antonsen KK, Klausen MK, Brunchmann AS, et al
Clinically, this makes GLP-1RA ideal for the management of Type 2 DM, which was the initial sole indication of this drug
Prescribers are reminded of the importance of this drug being taken exactly as directed: swallowed whole, first thing in the morning, with a sip (up to 120 mL) of water and with no food, drink or other medication for at least 30 minutes to ensure absorption and, therefore, efficacy (note that, although the Summary of Product Characteristics states that Rybelsus can be taken at any time of day provided it is taken on an empty stomach, since GLP-1 RAs delay gastric emptying it is likely that the best time to ensure the stomach is empty is first-thing in the morning, and this is usually recommended)
Eat More High-Fiber Foods to boost GLP-1 Eating foods that are high in fiber is one of the easiest ways to increase GLP-1
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