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These findings suggest that high baseline autophagic activity, particularly when coupled with elevated checkpoint expression, could serve as a biomarker for identifying patients who may benefit from combining autophagy inhibitors with immunotherapy, a hypothesis awaiting robust clinical validation

Schizophrenia (SCZ) is a severe and chronic psychiatric disorder that affects approximately 1% of the global population

Thermal stability assay Thermal stability was determined by measuring T m values according to a published protocol 60

By increasing insulin sensitivity in obese mice more than GLP- 1 receptor agonism, researchers show that tirzepatide is an effective insulin sensitizer