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SPPS (Solid-Phase Peptide Synthesis): This is the most common approach to upstream peptide manufacturing

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Cardiovascular disease (CVD) is the leading cause of death and disability-adjusted life-years (DALYs) related to high BMI

In the acute setting, this may include: Adrenaline (epinephrine) intramuscular injection if there are signs of anaphylaxis or airway compromise Antihistamines (e.g., cetirizine, chlorphenamine) to reduce swelling and allergic response in histaminergic angioedema Corticosteroids (e.g., prednisolone, hydrocortisone) to dampen inflammation, though their onset of action is slower Airway management and oxygen therapy if respiratory distress is present Observation in hospital until symptoms fully resolve, as angioedema can recur or worsen It's important to note that antihistamines and corticosteroids may be ineffective for bradykinin-mediated angioedema (such as that caused by ACE inhibitors or in hereditary/acquired C1-inhibitor deficiency)