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In a trial of WEGOVY injection in adult patients with type 2 diabetes and body mass index (BMI) greater than or equal to 27 kg/m2 for weight reduction (Study 3), hypoglycemia (defined as a plasma glucose less than 54 mg/dL) was reported in more patients treated with WEGOVY versus placebo [see Adverse Reactions (6.1)]

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There was no evidence demonstrating other significant safety issue differences (such as serious adverse events, adjudicated cardiovascular events) between combination therapy and monotherapy