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Description

This is further confounded by ligand-dependent or ligand-independent activation of ER

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Immediately afterMost patients resume normal activities straight away

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Under conditions of high glucose or photoinjury, GSH-synthesizing glutamate cysteine ligase (GCL) activity decreases, leading to GSH depletion and GPX4 inactivation, triggering a lipid peroxidation cascade (15)

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There is a broad clinical spectrum, but the proportion of patients with a severe clinical presentation and who are refractory to treatment - despite early detection by NBS - is larger than seen in VLCAD deficiency [62, 131]

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