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After binding to GLP-1 receptors in pancreatic beta cells, GLP-1 RAs exert their glucose-lowering effect by stimulating glucose-dependent insulin release

Ultimately, we need more data from larger clinical trials of these medications

8.5 Geriatric Use In the liraglutide injection treatment arms of the glycemic control trials, a total of 832 (19.3%) of the patients were 65 to 74 years of age and 145 (3.4%) were 75 years of age and over [see Clinical Studies (14.1)]

There is also debate regarding the potential for harm associated with PCSK9i use in patients with a history of HF, possibly mediated via unwanted effects on cardiac metabolism