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Review: Microbial transformations of human bile acids

10-13 In subsequent trials where higher doses of the GLP-1/GIP agonists were used in non-diabetic obese subjects, weight loss of 15% to 21% of body weight was seen

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Drug Discov Today 21(5):802818 Hamilton A, Hlscher C (2009) Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system