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Through integrated multi-omics approaches and rigorous mechanistic studies, we demonstrated how PRMT1-mediated post-translational modifications orchestrate a cascade of molecular events leading to TEC injury

Additionally, human ADMSCs significantly enhanced ovarian function and follicular development in PCOS rats by modulating epigenetic modifications, such as DNA methylation and histone deacetylation, and increasing estrogen receptor expression [134]

Conclusion This review underscores the therapeutic promise of ethnobotanical natural products in targeting oxidative stress, inflammation, and neurodegeneration across ocular pathologies

In this way, ALKBH5 directly downregulates CHAC1 and contributes to ferroptosis resistance in gastric cancer cells ( 2.3.2 CHAC1-mediated ferroptosis in cancer and neurological disorders: mechanisms and therapeutic implications Generally, cancer cell lines show a high variety in terms of sensitivity toward ferroptosis ( In ferroptosis resistant melanoma cells, CHAC1 was shown to be upregulated by NRF2 independent from ER stress signaling alongside the Aldo-Keto Reductase Family 1 Member C1 (AKR1C1) capable of degrading lipid radicals ( CHAC1 , most melanoma cell lines appear to be resistant against ferroptosis