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At room temperature storage, melatonin treatment reduced the relative membrane-leakage rate and inhibited the generation of superoxide radicals (O 2 ), ethylene synthesis, hydrogen peroxide (H 2 O 2 ) and malondialdehyde (MDA), resulting in prolonged freshness and a reduction in browning and degradation of chlorophyll/pigments in fruits and vegetables (176)

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GDNF strongly inhibits the inflammatory glial cells known as microglia, thereby decreasing inflammation, and perhaps slowing neurodegeneration [11]

Under normal physiological conditions, when cellular redox levels are stable, Nrf2 is sequestered in the cytoplasm by Keap1, which binds to Nrf2 through the cullin3 (Cul3) ubiquitin ligase-containing E3 complex [17]