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10.1016/j.ijpharm.2019.04.016 250 Torres-lvarezB.Mesa-GarzaI

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Alternative Names: Forkhead box protein O4, Proxofim, FOXO4a, AFX, AFX1, MLLT7 FOXO4-DRI Studies and Research Data Investigations in Insulin-Linked Pathways Research indicates that FOXO proteins may operate downstream of insulin and insulin-like growth factor signaling, with potential roles in cellular growth, oxidative stress regulation, and metabolic balance

However, the core downstream target genes mediating Nrf2-regulated DR iron metabolism and lipid peroxidation lack in-depth validation, and the optimal activation strategy, long-term safety of Nrf2 pathway and its crosstalk with other ferroptosis regulatory pathways remain insufficiently studied, warranting further investigation