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The expression of TK is decreased in thiamine deficiency [184]

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The swelling ratio (SR) was calculated as follows: SR = ( W a W b )/ W b 100%, where W a denotes the actual weight of the hydrogel sample at a given time, and W b denotes the initial weight of dry hydrogel

Simultaneously, higher S-adenosylmethionine (SAM) availability supports key methylation-dependent pathways, which are crucial for epigenetic regulation and gene expression related to energy metabolism