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We adapted to our constructs the reverse dimerization (RD) assay, originally designed for the synchronized trafficking of secretory and integral membrane proteins 27

The standard schedule begins at 0.3 mg weekly for four weeks, then escalates to 0.6 mg for four weeks, followed by 1.2 mg for four weeks, then 1.8 mg for four weeks, ultimately reaching the maintenance dose of 2.4 mg weekly

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Figure 2 3 Bone-brain axis The primary physiological function of bones has traditionally been viewed as protecting internal organs and facilitating movement