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The current descriptive catalog of CKD-associated microbiota alterations provides an essential foundation, but the field must now prioritize functional validation, causality testing through microbiota transplantation or defined consortia, and integration of multi-omics to identify actionable therapeutic targets

At the 10-year follow-up mark of an investigation of cardiometabolic outcomes of pediatric obesity, 30 of 376 cardiomyopathy-associated differentially methylated sites at baseline persisted, with 11 being linked to cardiac hypertrophy in adulthood [162]

Some studies have reported associations between HNMT genotype and ADHD-related traits, though results are mixed and no single gene explains the condition

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