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Kirkwood JM, Ibrahim JG, Sondak VK, Richards J, Flaherty LE, Ernstoff MS, Smith TJ, Rao U, Steele M, Blum RH: High-and low-dose interferon alfa-2b in high-risk melanoma: first analysis of inter-group trial E1690/S9111/C9190

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The FDA-approved pharmaceutical version (Vyleesi) comes as an autoinjector specifically because subcutaneous injection provides optimal bioavailability, but research chemical and compounded versions offer nasal spray alternatives for those unwilling or unable to inject