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10.1038/s41598-019-45744-5 52 XuJ.TianY

Interestingly, the severe chronic liver fibrosis induced by hepatitis B is closely associated with the hypermethylation of HOXA2 31

The increased oxidative stress seems to be the second hit in the progression from NAFL to NASH: the increase in ROS and consequently in lipid peroxidation has been associated to hepatocellular damage, inflammation, and eventual fibrosis due to the activation of hepatic stellate cells