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They found that placebo was associated with modest improvement in hyperphagia and repetitive behaviors in childhood PWS, whereas IN OT was not associated with improvement in these domains

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By evading this sequestration, IGF-DES is able to engage the IGF-1 receptor (IGF-1R) more directly, making it a uniquely valuable research tool for studying IGFBP-independent IGF-1 receptor signalling

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