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In any event, taken as a whole, our preclinical data point out that GLP1/E-based therapies would be superior than metformin also for an integral management of the metabolic and reproductive complications of milder cases of PCOS, with less severe metabolic alterations and preserved ovulatory function

[PMC free article] [PubMed] [CrossRef] Mescka CP, Guerreiro G, Hammerschmidt T, et al

A1: Samaglutide is a long-acting GLP1 receptor agonist with high structural homology to human glucagon-like peptide1

Clinical trials for Zepbound showed that participants achieved an average weight loss of 15% to 22.5%, depending on dosage, with results tracked over 72 weeks under controlled conditions