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Mutations in JAGN1, which lead to reduced MPO expression within NETs, impair antifungal killing capacity, highlighting MPO as another critical NET-associated biomarker for fungal clearance [55, 112, 113]

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A low-calorie diet is the standard recommendation for patients with PWS to achieve weight management, and several types of diets have been suggested, i.e., a low-fat low-calorie diet, a modified plant-based food pyramid, and the red, yellow, green diet, which prefers plant foods restricting high-fat and high-energy ones [90, 91]

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GLP-1 receptor agonists, SGLT2 inhibitors and DPP-4 inhibitors GLP-1 receptor agonists, sodium glucose co-transporter-2 (SGLT2) inhibitors and dipeptidyl peptidase-4 (DPP-4) inhibitors reduce the risk of MACE compared to placebo

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