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These medications reduce hyperglycemia (Hb1Ac reduction of 0.8 1.4%) through the inhibition of glucose reabsorption in the proximal convoluted tubule of the kidney and the resulting increase in glycosuria ( In light of this evidence, these therapies have opened a new paradigm not only for the management of altered glucose metabolism in T2D but also in consideration of their pleiotropic effects ( Emerging data indicate that the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis may play a role in either mediating the metabolic and neuroendocrine effect of these drugs or responding to the profound body modifications fostered by GLP-1RAs and SGLT-2is

[DOI] [PMC free article] [PubMed] [Google Scholar] Kim G.-J

The findings demonstrated that the supplementation of leonurine to the culture medium led to a reduction in ROS levels by approximately 1.9 times and an increase in GSH levels by 1.6 times, in comparison to the control group (Fig

Hepatol Res 47(10):10721078