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The evidence suggests that weight loss is the primary driver of the reproductive improvements seen with semaglutide, as substantial weight reduction is known to improve hormone balance, ovarian function and fertility in women with PMOS. Clare Thompson, MBBS, BSc, nMRCGP However, GLP-1 drugs may also have direct effects on reproductive health via mechanisms such as insulin signalling and ovarian function

Root Cause: In facility settings, payers may include injection administration fees in the global facility reimbursement and reject separate claims for the procedure

Risk Stratification Considerations Enhanced Monitoring for Certain Patients: Certain patient populations warrant enhanced monitoring intensity