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Obesity is a leading risk factor for mortality in the U.S., Lakdawalla says

Because Wegovy (when approved at its highest dose) produces rapid weight loss and sharper metabolic shifts, this could drive the stronger association by predisposing to optic nerve hypoperfusion through intravascular volume contraction, hypotension with nocturnal dips and autonomic instability. For ophthalmologists, the findings highlight a potential safety signal that warrants further investigation but should be interpreted cautiously

The mechanism by which GLP-1RAs are thought to impact wound healing is likely through modulating immune effects, and improvement was seen in normoglycemic mice, suggesting a mechanism independent of glucose control

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