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The mechanisms by which inflammation affects tight junction structure and function and transcellular mechanisms such as endocytosis are largely unknown, although reproducible correlations have been observed between the severity of experimental and clinical disease and on the one hand and transepithelial electrical resistance, transport of paracellular markers, and systemic LPS concentrations and on the other [42, 86]

The degree of pericyte loss or degeneration directly correlates with the magnitude of functional changes in the vasculature, underscoring their critical role in preserving cerebral homeostasis

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Zia S, Traetta ME, Baaklini CS et al (2025) Age-impaired remyelination is associated with dysregulated microglial transitions