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These pathways may involve both receptor-dependent and receptor-independent mechanisms related to metabolic regulation

Notably, in these studies, the upregulation of GPx4 has been achieved by using exogenous agents (like NVP-AUY922, Bafilomycin A1, PD151746, GsMTx4, epigallocatechin-3-gallate, total flavonoids of Engelhardia roxburghiana leaves, Lycium barbarum polysaccharide-glycoprotein, perillaldehyde, melotonin, ferulic acid, and sphingosine-1-phosphate) which either inhibit the degradation of GPx4 or increase its transcription by activating the Nrf2 [67]

In a large study from Ontario, Canada, evaluating cirrhosis in pregnancy, MASLD was the leading cause of liver disease, surpassing viral hepatitis, autoimmune liver disease, and other causes of chronic liver disease (19)

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