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472,473 To overcome the heterogeneity and adaptability of tumor metabolism, enhance the specificity of targeted drugs, minimize adverse effects, and hinder the occrurence of treatment resistance, novel investigations in targeted therapy focus on devising novel small-molecule inhibitors, developing robust delivery systems that adhere to the 3 R delivery principle (right site, right timing and right dose) and exploring rational and effective drug combination strategies

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23 however, there remains a significant treatment gap in weight management between that attained with GLP-1 RA and bariatric surgery (Figure 4)