glp-1 receptor structure Agonists Structure of Semaglutide-bound Glucagon-Like Peptide-1

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Tirzepatide, approved for T2DM and obesity, achieves data-proven superior glycemic control (HbA1c reductions of 2.02.5%) and weight loss (1520% of body weight) compared to GLP-1 agonists, such as semaglutide [14]

The plot shows the absolute standardized mean difference between the group of patients who initiated GLP-1RA or BI for each variable before and after propensity score matching