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Tolerance development - Some individuals find that appetite suppression diminishes over time, requiring dose adjustments or additional strategies Maintenance is a separate challenge - Many people regain weight after discontinuing GLP-1 medications

While clinical trials adhere to standardised titration protocols to evaluate efficacy, clinical practice allows for a slower, individualised approach, particularly for patients experiencing early GI symptoms

A 2023 quality-control survey of compounded GLP-1 products (USP and FDA joint sample) found that 1.3% of vials surveyed had visible signs of degradation, almost all linked to shipping or storage temperature excursions rather than compounding errors

Wegovy is priced at $1,349 per package, including four pens, each pre-filled with a single dose of the medication