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Although the liver injury caused by Polygonum multiflorum has received attention, our previous studies have shown that the liver injury caused by Polygonum multiflorum is specific, and its main pharmacodynamic component, TSG, is safe and effective [271]

Depressive-like behavior In rats, supplementation with a high fat diet (HFD)(G14-P21) aggravated the PRS-induced depressive-like behavior in old males in the FST at M19-20 [121]