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6e) is productive regarding the formation of glutathionylated enzyme

Hence, similar to HMGR with two N-terminal transmembrane regions and multimerization among the catalytic domains (Friesen and Rodwell, Overexpression of active G6PD5 should lead to accumulation of 6-phosphogluconolactone (6PL), and if not channeled instantly by a PGL (Lansing et al., Figures 3C,D, 6), interaction at the ER seems to occur mainly between membrane-bound proteins

doi: 10.1080/09712119.2015.1091339 109

Hydrogen peroxide has a longer half-life than superoxide, and unlike superoxide, hydrogen peroxide can transfer across lipid membranes by either diffusion or transport through channels, such as aquaporins (38)