action of glp 1 agonist GLP1-GIP receptor co-agonists: a promising evolution in the treatment type 2 diabetes | Acta Diabetologica Mechanisms of action of GLP-1RA.

Vogt NM, Kerby RL, Dill-McFarland KA, Harding SJ, Merluzzi AP, Johnson SC, et al

LiYZhaoTLiJXiaMLiYWangXet alOxidative stress and 4-Hydroxy-2-Nonenal (4-Hne): Implications in the pathogenesis and treatment of aging-related diseases

However, further large-scale, well-designed clinical trials are needed to determine the appropriate dosages, treatment duration, and patient selection criteria

Someone carrying extra weight who still runs half marathons, with normal blood sugar, normal labs, and good energy, has what the commission calls preclinical obesity: a state worth watching, with elevated future risk, but not necessarily one that demands aggressive treatment today