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Joint pain during tirzepatide treatment may result from rapid weight loss altering biomechanics and joint loading, increased physical activity unmasking pre-existing joint issues, or underlying conditions like osteoarthritis that are common in patients with obesity and type 2 diabetes

Your provider can map out the right cadence using your lab results and personal goals

^Based on a 6-month clinical trial (n=180) of individuals who were enrolled between FebruaryApril 2024, with overweight or obesity taking semaglutide or tirzepatide for weight loss and related outcomes through the WW Clinic Program and participating in the GLP-1 companion nutrition program

When to decrease dose Consider decreasing if: Persistent side effects that don't resolve Excellent results achieved and maintenance desired Budget constraints require conservation Stacking and wanting to optimize ratios Many researchers find they can reduce dose during maintenance phases after achieving initial goals during more intensive loading phases