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However, it's worth noting that peptides such as palmitoyl tripeptide-5 (Syn-Coll) may further stimulate the proliferating effects of retinol and potentially increase the risk of side effects related to hyperproliferation

Indeed, studies in transgenic mice reveal that epithelial-specific overexpression of IGF-1R induces mammary tumors with basal-like characteristics whereas epithelial-specific down-regulation of IGF-1R produces tumor with a more claudin-low molecular profile [91]

This would allow a higher degree of efficacy when compared to tablet or capsule administration [25, 26]