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GLP-1 receptor agonists may be a good fit for individuals who: Have struggled with weight loss despite lifestyle changes

Serial measurements were analyzed by using two-way ANOVA with Tukeys post hoc test using Sigma Stat 3.5 program and figures were performed by using SigmaPlot 10.0 program (Systat Software Inc)

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In contrast with the effect of GIPR blockade, pretreatment with the GLP-1R antagonist exendin (9-39) (Ex-9) had no effect on nutrient-mediated AgRP neuron inhibition (Figure 2)