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They are not approved by the FDA or EMA as drugs for specific indications related to mitochondrial energy or aging

Vitamin B12 Deficiency and Management During Pregnancy In addition to anaemia, symptoms of vitamin B12 deficiency may include: Fatigue Breathlessness Nervous system symptoms such as numbness, tingling or poor balance Poor concentration or memory Paleness Mood changes, including low mood, anxiety or disrupted sleep Some women are more susceptible to vitamin B12 deficiency than others

Kontush A, Lhomme M, Chapman MJ

The valeric acid was positively correlated with Bifidobacterium , Pseudomonas , and norank_f_Peptococcaceae , and negatively correlated with [Eubacterium]_fissicatena_group