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Abbreviations ABC ATPbinding cassette ApN aminopeptidase N BSO buthionine sulfoximine CysGly cysteinylglycine EAATs excitatory amino acid transporters GCL glutamatecysteine ligase GCLm modifier subunit of GCL GlyT glycine transporters GPx glutathione peroxidase(s) GR glutathione disulfide reductase GSB glutathionebimane adduct GSH glutathione GSSG glutathione disulfide GST glutathione Stransferase LDH lactate dehydrogenase Mrp multidrug resistance protein(s) MRS magnetic resonance spectroscopy MTT 3(4,5dimethyl2thiazolyl)2,5diphenyl2Htetrazolium bromide NAC Nacetyl cysteine PPP pentosephosphate pathway PrP prion protein ROS reactive oxygen species GluCys glutamylcysteine GT glutamyl transpeptidase 1

doi: 10.1016/j.neuron.2016.06.033 22 YuYZengZXieDChenRShaYHuangSet al

Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021