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Another study found that people taking Wegovy lost a similar amount of weight over a 68-week period, results that surpass any previous obesity drugs

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In an inflammatory state, knockout of Clec16a in cells can significantly increase apoptosis and sharply increase blood glucose levels in patients, and hyperglycemia further affects mitochondrial quality control, promotes cell damage, and exacerbates diabetes

Cocaine Only limited clinical evidence is available for GLP-1RAs in cocaine misuse: a small ( N = 13) proof-of-concept trial across 2 days showed that exenatide compared with placebo did not reduce the number of self-administered cocaine infusions 115 , while a case series of 3 individuals with cocaine-use disorder highlighted the feasibility and safety of using the same drug over 6 weeks, although no efficacy measures were reported 116