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Patients seeking B12 testing or treatment should consult their GP, who can arrange appropriate blood tests (serum B12, full blood count, folate, and if indicated, intrinsic factor and parietal cell antibodies) and prescribe treatment if deficiency is confirmed

Inhibition of DNA replication in maturing red blood cells results in the formation of large, fragile megaloblastic erythrocytes

Management: o Avoid concurrent use unless prescribed with Carbidopa

Tirzepatides dual receptor agonism generally leads to fewer GI complaints than Semaglutide, since the 20-30% incidence rate with Semaglutide drops to under 5% with Tirzepatide in experienced clinical hands