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Meanwhile, challenges such as acquired resistance, adaptive signaling, and tumor microenvironment remodeling continue to limit the durability of KRAS-targeted therapies

However, the very short half-life means effects remain largely confined to tissues near the injection site before rapid degradation

284 Emerging epigenetic data suggest that GLP-1 RAs may decelerate biological aging via DNA methylation modifications at loci associated with inflammatory and metabolic regulation, consistent with observed reductions in biological age

Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling