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Most people notice the first changes in physique and body circumferences after about 2-4 weeks of systematic use, while maintaining healthy eating habits

Newer agents such as tirzepatide (a dual GIP/GLP-1 receptor agonist) may offer different tolerability profiles, though gastrointestinal effects remain common and availability on the NHS may be limited pending NICE appraisal and local commissioning decisions

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Methods This is secondary analysis of a randomized controlled trial involving 193 adults with obesity (age 1865 years, body mass index 3243 kg/m 2 ) without diabetes mellitus who completed an 8-week low-calorie diet and were subsequently randomized (1:1:1:1 ratio) to: exercise plus placebo