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While previous research has indicated polytherapy as a risk factor for hypocarnitinemia in patients with epilepsy (13, 15, 17, 19), our analysis demonstrates no statistically significant associations between taking multiple ASMs and hypocarnitinemia

Time Course Differences PT-141 and Melanotan 2 also differ in pharmacokinetic characteristics that affect research design: PT-141: Shorter half-life, faster onset of effects, briefer duration Melanotan 2: Longer half-life, more sustained effects, longer research protocol implications Research designs investigating acute mechanism activation may prefer PT-141's shorter time course

doi: 10.1126/science.aay5356 13 MillarJEFanningJPMcDonaldCIMcAuleyDFFraserJF

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